Peer-reviewed veterinary case report
Mineral differences in hair of dogs with medial coronoid process
By Davies, M et al.·Published in The Veterinary record·2017·The Old School House, United Kingdom·View original on PubMed →
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Original publication title: Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry.
- Species:
- dog
Plain-English summary
A group of dogs with a condition called medial coronoid process disease (MCPD), which affects their elbow joints, had lower levels of important minerals like copper, sulfur, and zinc in their hair compared to healthy dogs. This study suggests that these mineral imbalances could play a role in the development of MCPD. The findings indicate that checking a dog's hair for mineral content might help identify puppies at risk for this condition. More research could help veterinarians use this information to prevent or manage MCPD in dogs.
People also search for: dog elbow pain · medial coronoid process disease in dogs · puppy mineral deficiency symptoms
Abstract
In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry. Dogs were of similar age (control, 4.05 [1.85-7.70] v MCPD, 4.30 [3.25-6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P<0.001). Age, sex and neutered status had no effect on hair mineral status. Based on hair analysis, a role for mineral imbalance including copper, sulphur and zinc in the aetiopathogenesis of canine MCPD is suggested. Hair mineral analysis may prove useful as a biomarker for susceptible puppies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28219956/