Peer-reviewed veterinary case report
MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease.
- Journal:
- Neuroscience bulletin
- Year:
- 2014
- Authors:
- Tian, Ning et al.
- Affiliation:
- Beijing Obstetrics & Gynecology Hospital · China
- Species:
- rodent
Abstract
MicroRNA alterations have been reported in patients with Alzheimer's disease (AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD pathology by downregulating BDNF.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24604632/