Peer-reviewed veterinary case report
Mirabegron poisoning in dogs causes fast heart rate and redness
By Schmid, Renee D & Hovda, Lynn R·Published in Journal of medical toxicology : official journal of the American College of Medical Toxicology·2018·Pet Poison Helpline, United States·View original on PubMed →
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Original publication title: Mirabegron Toxicosis in Dogs: a Retrospective Study.
- Species:
- dog
Plain-English summary
Several dogs experienced symptoms after accidentally ingesting mirabegron, a medication used for overactive bladder in humans. The most common signs included a fast heartbeat and skin redness, but many dogs showed no symptoms at all, and thankfully, there were no deaths reported. The doses ingested varied widely, but the overall findings suggest that while mirabegron can be toxic to dogs, the effects may not always be severe in real-life situations. If your dog has ingested this medication, it's important to contact your veterinarian for advice.
People also search for: dog mirabegron poisoning symptoms · fast heartbeat in dogs · what to do if my dog ate human medication
Abstract
Mirabegron is a selective beta (B)adrenoreceptor agonist marketed for human treatment of an overactive bladder (OAB). It has a wide margin of safety in humans, but in dogs, severe adverse effects have occurred. We sought to determine the effects and outcome of mirabegron toxicosis in dogs. A retrospective review of all calls within the Pet Poison Helpline (PPH), an international animal poison control center, database was performed for mirabegron exposures between 2013 and 2015. Potential ingested doses ranging from 1.31 to 8.3 mg/kg. Many dogs remained asymptomatic and no fatalities occurred in any dogs. The most commonly reported signs were tachycardia and erythema. While mirabegron was found to have a very narrow margin of safety and high toxicity risk to dogs during preclinical trials, effects appear to differ greatly in the nonclinical field environment and further study is needed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29255997/