Peer-reviewed veterinary case report
Mitochondrial DNA changes linked to malignant cancers in dogs
By Slaska, Brygida et al.·Published in Mitochondrial DNA·2014·Department of Biological Bases of Animal Production·View original on PubMed →
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Original publication title: Mitochondrial D-loop mutations and polymorphisms are connected with canine malignant cancers.
- Species:
- dog
Plain-English summary
A study found that certain genetic changes in the mitochondrial DNA (mtDNA) of dogs are linked to malignant cancers. In particular, tumors of epithelial origin showed mutations in the D-loop sequence, which is part of the mtDNA, in a significant number of cases. These mutations were identified in specific types of skin cancers, suggesting that they may contribute to the development of cancer in dogs. The findings indicate that monitoring these genetic changes could help in understanding and potentially treating canine cancers more effectively.
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Abstract
Abstract The aim of the conducted investigations was to identify differences in the D-loop nucleotide sequence between neoplastic tissue, normal tissue, and blood and to determine their correlation with the type of cancer in dogs. In 62.5% of the analyzed tumors of epithelial origin and 25% tumors of mesenchymal origin, substitution was detected within the D-loop sequence between the neoplastic tissue, normal tissue, and blood. Two mutations occurring in the carcinogenic process in position T15620C have been identified in epithelioma glandulae sebacei and carcinoma planoepithelialae keratodes. Blood and cancer heteroplasmy was diagnosed for carcinoma planoepithelialae keratodes and "Comedo" carcinoma. The results of the study indicate that polymorphic changes in the D-loop sequence promote carcinogenesis in dogs. Heteroplasmy diagnosed in blood and tumor cells and absence thereof in normal tissue may imply mtDNA recombination. High prevalence of mtDNA mutations in canine tumors may suggest mtDNA genetic instability, which is likely to play a role in carcinogenesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23656294/