Mitochondrial dysfunction in equine ageing: Current evidence and clinical implications for geroscience

Abstract

Abstract Ageing is a complex biological process affecting a growing geriatric human and equine population worldwide. Mitochondrial dysfunction is considered one of the hallmarks of ageing, representing a multifaceted process. This review synthesises current findings on mitochondrial dysfunction in aged equines, drawing parallels with human medicine and identifying current knowledge gaps. Integrating findings from human and equine research may bridge existing challenges and offer new opportunities, including the development of novel translational models for ageing research. Furthermore, it highlights the need for mitochondrial research in aged horses to enable accurate prevention strategies, treatment plans, and management of geriatric horses, ensuring their welfare.