Peer-reviewed veterinary case report
Dog with pituitary Cushing's and adrenal tumor resistant to mitotane
By Bennett, P F & Norman, E J·Published in Australian veterinary journal·1998·Companion Animal Referral Service·View original on PubMed →
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Original publication title: Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma.
- Species:
- dog
Plain-English summary
A dog with a two-year history of excessive thirst and urination was diagnosed with a hormone disorder called pituitary-dependent hyperadrenocorticism (Cushing's disease). Despite treatment with a medication called mitotane, the dog's symptoms did not fully improve. Unfortunately, the dog later collapsed and showed signs of liver disease, leading to euthanasia. An examination after death revealed a tumor on the adrenal gland and extensive spread to the liver, which contributed to the dog's condition.
People also search for: dog excessive thirst and urination · Cushing's disease treatment for dogs · dog liver disease symptoms
Abstract
A dog was presented with a 2 year history of polyuria and polydipsia due to pituitary-dependent hyperadrenocorticism. A low-dose dexamethasone suppression test and measurement of plasma ACTH concentration confirmed the diagnosis. Treatment was instituted with mitotane at 44 mg/kg/day and then 88 mg/kg/d without complete resolution of signs. The dog collapsed with signs consistent with liver disease and was euthanased. Necropsy revealed a phaeochromocytoma of the left adrenal medulla with extensive metastases to the liver. A chromophobe adenoma of the pars intermedia of the pituitary was found.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9578778/