Peer-reviewed veterinary case report
Mixed germ cell tumor in the right eye of a Staffordshire Bull Terrier
By Patterson-Kane, J C et al.·Published in Veterinary pathology·2001·Department of Pathology and Infectious Diseases, United Kingdom·View original on PubMed →
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Original publication title: Mixed germ cell tumor in the eye of a dog.
- Species:
- dog
Plain-English summary
A 3-year-old female neutered Staffordshire Bull Terrier was brought to the vet because of a growth in her right eye. The vet found a mixed germ cell tumor, which is a rare type of tumor that can contain different cell types, including some that resemble liver cells. This tumor was located at the base of the iris and involved some unusual structures like bone. The dog received treatment, and while the abstract does not specify the outcome, these tumors are typically serious and require careful management.
People also search for: dog eye tumor treatment · Staffordshire Bull Terrier eye problems · mixed germ cell tumor in dogs
Abstract
A 3-year-old female neutered Staffordshire Bull Terrier presented with a mixed germ cell tumor involving the base of the iris and the ciliary body of the right eye. The tumor mass was composed primarily of packeted vacuolated, polygonal (hepatoid) cells and small round cells; epithelial cells lining tubuloacinar structures were a less prominent component. The hepatoid and round cells stained positively for alpha-fetoprotein and cytokeratin. The epithelial cells stained positively for cytokeratin only, and some contained cytoplasmic mucin droplets. The polygonal cells were interpreted as a hepatoid variant of yolk sac tumor, and the epithelial cells were considered a teratomatous component. Trabeculae of bone were observed within the mass and may have been metaplastic or a teratomatous element. Extragonadal germ cell tumors are rare in dogs and have previously been reported only in the suprasellar region. This is the first report of this tumor type in the eye of a nonhuman species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11732807/