Peer-reviewed veterinary case report
Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse.
- Journal:
- Psychopharmacology
- Year:
- 2010
- Authors:
- Reichel, Carmela M & See, Ronald E
- Affiliation:
- Department of Neurosciences · United States
- Species:
- rodent
Abstract
RATIONALE: Modafinil (Provigil) is a wake-promoting drug characterized by cognitive enhancing abilities. Recent clinical data have supported the use of modafinil for treatment of chronic psychostimulant addiction and relapse prevention. MATERIALS AND METHODS: We used an intravenous methamphetamine (meth) self-administration procedure to assess the dose-dependent effects of modafinil on reinstatement following abstinence and after extinction on conditioned-cue and meth-primed reinstatement of meth seeking. RESULTS: Modafinil attenuated active lever responding in multiple reinstatement conditions-context-induced, conditioned cue, and meth prime. The most pronounced and consistent effect was on meth-primed reinstatement, and modafinil did not reinstate meth seeking when tested alone. DISCUSSION: These findings support clinical findings in humans that modafinil may be an effective therapeutic agent for the prevention of relapse in abstinent meth users.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20352413/