Peer-reviewed veterinary case report
Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative.
- Journal:
- CPT: pharmacometrics & systems pharmacology
- Year:
- 2018
- Authors:
- Schneider, Benjamin et al.
- Affiliation:
- Department of Biomedical Sciences · United States
Plain-English summary
Researchers are looking at how to improve the way we study diseases that affect both humans and animals, particularly by using computer models. They believe that the traditional methods, which often rely on lab rodents, might not fully capture how these diseases work in people. By using data from both humans and animals with similar health issues, they hope to develop treatments that can benefit both fields. This approach, known as "reverse translation," emphasizes the need for better tools to help us understand and apply findings across different species. Overall, this research aims to enhance drug development for both veterinary and human medicine.
Abstract
There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This "reverse translational" approach needs to be supported by continuing efforts to refine the in silico tools that allow extrapolation of results between species.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29178333/