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Peer-reviewed veterinary case report

Model of immunogenic uveitis in rabbits.

Journal:
Bulletin of experimental biology and medicine
Year:
2006
Authors:
Neroev, V V et al.
Affiliation:
Helmholtz Institute of Ocular Diseases

Abstract

Six models of experimental immunogenic uveitis induced by injection of normal horse serum were tried in rabbits. A convenient working variant of the model was developed characterized by high activity and long duration of the inflammatory process in the eye. Creation of this model requires pre-sensitization (subcutaneous injection of 5 ml normal horse serum) followed by intravitreal injection of the resolving dose of horse serum on day 9. An adapted improved model of experimental immunogenic uveitis in rabbits is proposed.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/17415484/