Peer-reviewed veterinary case report
Modeling Murine Gastric Metaplasia Through Tamoxifen-Induced Acute Parietal Cell Loss.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2016
- Authors:
- Saenz, Jose B et al.
- Affiliation:
- Washington University School of Medicine · United States
- Species:
- rodent
Abstract
Parietal cell loss represents the initial step in the sequential progression toward gastric adenocarcinoma. In the setting of chronic inflammation, the expansion of the mucosal response to parietal cell loss characterizes a crucial transition en route to gastric dysplasia. Here, we detail methods for using the selective estrogen receptor modulator tamoxifen as a novel tool to rapidly and reversibly induce parietal cell loss in mice in order to study the mechanisms that underlie these pre-neoplastic events.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27246044/