Peer-reviewed veterinary case report
Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes.
- Journal:
- Advances in experimental medicine and biology
- Year:
- 2013
- Authors:
- Hapuarachchi, Tharindi et al.
- Affiliation:
- University College London · United Kingdom
Abstract
We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23852512/