Peer-reviewed veterinary case report
Models of cardiovascular disease: measurement of arrhythmogenic/antiarrhythmic activity in the guinea pig.
- Journal:
- Current protocols in pharmacology
- Year:
- 2009
- Authors:
- Guillaume, Philippe et al.
- Affiliation:
- Porsolt and Partners Pharmacology · France
- Species:
- rodent
Abstract
The protocols described in this unit are used to assess the effects of new chemical entities on arrhythmias in the guinea pig. In the anesthetized guinea pig, arrhythmias are induced by a slow intravenous infusion of digoxin, which provokes extrasystoles, ventricular tachyarrhythmias, and ultimately cardiac arrest. Imipramine precipitates the occurrence of arrhythmias, whereas propranolol shows protection against them.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22294396/