Peer-reviewed veterinary case report
Models of neurological disease (substance abuse): self-administration in monkeys.
- Journal:
- Current protocols in pharmacology
- Year:
- 2011
- Authors:
- Platt, Donna M et al.
- Affiliation:
- New England Primate Research Center/Harvard Medical School · United States
Plain-English summary
This research looks at how monkeys can be used to study drug addiction by allowing them to give themselves drug injections. This method helps scientists understand how drugs affect behavior, which is similar to how humans might use drugs. By observing how monkeys respond to different drugs, researchers can learn about the potential for abuse and test new treatments for addiction. The study includes methods for working with both large monkeys, like rhesus macaques, and smaller ones, like squirrel monkeys. Overall, this approach provides valuable insights into drug use and addiction.
Abstract
Drug self-administration is a procedure in which a subject performs a specified response that results in the delivery of a drug injection. This procedure is viewed as a relevant model for the study of human drug-taking behavior. Drug self-administration in primates has several characteristics that resemble drug-taking behavior in humans, and agents commonly abused by humans also generally maintain self-administration behavior in monkeys. Self-administration procedures allow for the study of a variety of drug properties. For instance, they can be used to investigate the abuse potential of new compounds and to study the effects of candidate medications for the treatment of drug addiction. These procedures can also be employed for examining drug reinforcement mechanisms. Described in this unit are procedures for studying intravenous drug self-administration in large primates, such as rhesus macaques, and smaller primates, such as squirrel monkeys.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22382996/