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Peer-reviewed veterinary case report

Models of visceral pain: colorectal distension (CRD).

Journal:
Current protocols in pharmacology
Year:
2004
Authors:
Jones, R Carter W & Gebhart, G F
Affiliation:
The University of Iowa · United States
Species:
rodent

Abstract

The visceromotor response to balloon distension of the colon is a robust behavioral model of visceral nociception in rodents and is ideally suited for studying the visceral antinociceptive activity of drugs. This unit describes, in detail, quantification of this response with the use of electromyography in both rats and mice.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/22294123/