Peer-reviewed veterinary case report
Gene analysis of canine adenovirus 2 in coughing dogs
By Kalinowski, M et al.·Published in Polish journal of veterinary sciences·2012·Department of Epizootiology and Infectious Diseases·View original on PubMed →
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Original publication title: Molecular analysis of a fragment of gene E1B 19K of canine adenovirus 2 (CAV-2) isolated from dogs with symptoms of cough.
- Species:
- dog
Plain-English summary
A group of 20 dogs, aged 1 to 9 years, were brought in with coughing and other signs of upper respiratory infections. Tests showed that 16 of these dogs were infected with a virus called canine adenovirus 2 (CAV-2). Researchers found three different genetic variants of the virus among the dogs, indicating that the infections were caused by a stable strain of the virus common in that region. While the study focused on the genetic details of the virus, it highlights the importance of monitoring respiratory infections in dogs, especially in areas where this virus is prevalent.
People also search for: dog cough treatment · canine adenovirus symptoms · upper respiratory infection in dogs
Abstract
The aim of this study was to perform molecular analysis of canine adenovirus 2 (CAV-2) E1B 19K gene fragment isolated from 20 dogs of various breeds (12 males and 8 females aged 1-9 years), with clinical symptoms of upper respiratory tract infections, from the Lubelszczyzna region. Nasal swabs were taken from dogs. DNA of CAV-2 was detected using the PCR method in 16 swabs. All PCR products were sequenced, and the obtained sequences were compared with each other and with the sequence of the E1B 19K gene of the CAV-2 strain from an online database of NCBI GenBank: AC 000003. Based on analysis of the obtained sequences, three polymorphic variants of CAV-2 (No. 1-3) with homology of 78 - 100% were distinguished. The nucleotide and amino acid sequences of the most frequently represented polymorphic variant, No. 1, differed from the sequences of polymorphic variant No. 2 with one substitution. The nucleotide and amino acid sequence of the E1B 19K gene of CAV-2 AC 000003 differed from the analogous sequences of representatives of variant No. 1 with 44 nucleotide and 19 amino acid substitutions. The small number of nucleotide differences in the E1B 19K CAV-2 gene among the examined own isolates, compared with AC 000003, suggest that the infections in dogs were caused by a relatively genetically stable virus which occurs in eastern
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23214360/