Peer-reviewed veterinary case report
No evidence papillomavirus causes oral cancer in dogs
By Munday, John S et al.·Published in Veterinary journal (London, England : 1997)·2015·Institute of Veterinary·View original on PubMed →
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Original publication title: Molecular and immunohistochemical studies do not support a role for papillomaviruses in canine oral squamous cell carcinoma development.
- Species:
- dog
Plain-English summary
A study looked at 28 dogs with oral squamous cell carcinoma (OSCC), a type of mouth cancer, to see if papillomaviruses (PVs) might be causing it. While some tumors showed high levels of a protein (p16) that can indicate a viral infection in humans, tests did not find any PV DNA in the tumors. This suggests that, unlike in humans, papillomaviruses are not a significant cause of mouth cancer in dogs. The findings help clarify the causes of this serious condition in pets.
People also search for: dog mouth cancer causes · oral squamous cell carcinoma in dogs · papillomavirus in dogs
Abstract
Oral squamous cell carcinomas (OSCCs) are common neoplasms of dogs and are of unknown cause. Whereas papillomaviruses (PVs) are an established cause of human OSCCs, few studies have investigated canine OSCCs for a PV aetiology. In humans, a PV aetiology can be determined by detecting PV DNA and PV-induced increased p16(CDKN2A) protein (p16) within the OSCC. In this study, PCR, using four different primer sets and p16 immunohistochemistry, was used to evaluate 28 canine OSCCs for a possible PV aetiology. None of the primers amplified PV DNA from any of the OSCCs although four neoplasms contained intense p16 immunostaining. Intense p16 immunostaining would indicate a PV aetiology in a human OSCC but the absence of PV DNA suggests that the increase in p16 was not due to PV infection. Overall the results indicated that PVs are not a significant cause of canine OSCCs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25956344/