Peer-reviewed veterinary case report
NDM-5 antibiotic resistance found in dog and cat in South Korea
By Hong, Jun Sung et al.·Published in Microbial drug resistance (Larchmont, N.Y.)·2020·Department of Laboratory Medicine and Research Institute of Bacterial Resistance, South Korea·View original on PubMed →
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Original publication title: Molecular Characteristics of NDM-5-Producingfrom a Cat and a Dog in South Korea.
- Species:
- cat
Plain-English summary
A dog and a cat in South Korea were found to have a rare type of bacteria that can resist many antibiotics, known as NDM-5-producing Enterobacteriaceae. Both pets were hospitalized in different veterinary clinics, and tests showed that the bacteria were genetically similar, indicating they may have transmitted the infection between them. This is the first time such bacteria have been reported in a cat in South Korea. The findings highlight the importance of monitoring antibiotic resistance in pets, as it can pose a risk to their health and potentially to humans as well.
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Abstract
Carbapenemase-producing Enterobacteriaceae (CPE) have been very rarely reported in companion animals in South Korea. In this study, we aimed to investigate the molecular characteristics and relatedness of two New Delhi metallo-β-lactamase (NDM-5)-producingisolates from rectal swabs of a dog and a cat hospitalized in different veterinary hospitals in South Korea during 2019. Antimicrobial susceptibility was tested by the Etest and broth microdilution method. PCR and sequencing were performed to detect antimicrobial resistance genes. Plasmid replicon typing and Southern blotting hybridization were performed to determine the replication origin of the plasmid and location of thegene, respectively. Their macrorestriction profiles forisolates were assessed by multilocus sequence typing (MLST) and pulse-field gel electrophoresis (PFGE). The two carbapenem-resistantisolates harbored thegene located on the IncX3 plasmid. Allele sequence analysis for MLST showed that the twoisolates were attributed to sequence type 410 (ST410). The NDM-5-producingisolate from the cat presented high clonal similarity (94%) assessed by PFGE to a previously reported NDM-5-producingST410 isolate from a dog hospitalized in the same hospital in 2017. The twoisolates for the genetic environment surrounding thegene had the same structure: IS-----IS. This study revealed a direct transmission of the NDM-5-producingST410 isolate between a dog and a cat. This is the first report of NDM-5 carbapenemase-producingsolate from a cat in South Korea.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32043911/