Peer-reviewed veterinary case report
Canine parvovirus variant CPV2c found in vaccinated dogs in Argentina
By Calderon, Marina Gallo et al.·Published in Journal of virological methods·2009·Centro de Virologí·View original on PubMed →
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Original publication title: Molecular characterization of canine parvovirus strains in Argentina: Detection of the pathogenic variant CPV2c in vaccinated dogs.
- Species:
- dog
Plain-English summary
A group of dogs in Argentina showed symptoms of parvovirus disease, which can include severe vomiting and diarrhea. Testing revealed that 27 out of 38 dogs were infected with different strains of canine parvovirus, including a new variant called CPV2c that can affect both vaccinated and unvaccinated dogs. This variant has been present in the dog population since at least 2003. The findings highlight the importance of keeping vaccinations up to date, as even vaccinated dogs can be at risk for this strain.
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Abstract
PCR amplification with sequence-specific primers was used to detect canine parvovirus (CPV) DNA in 38 rectal swabs from Argentine domestic dogs with symptoms compatible with parvovirus disease. Twenty-seven out of 38 samples analyzed were CPV positive. The classical CPV2 strain was not detected in any of the samples, but nine samples were identified as CPV2a variant and 18 samples as CPV2b variant. Further sequence analysis revealed a mutation at amino acid 426 of the VP2 gene (Asp426Glu), characteristic of the CPV2c variant, in 14 out of 18 of the samples identified initially by PCR as CPV2b. The appearance of CPV2c variant in Argentina might be dated at least to the year 2003. Three different pathogenic CPV variants circulating currently in the Argentine domestic dog population were identified, with CPV2c being the only variant affecting vaccinated and unvaccinated dogs during the year 2008.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19490967/