Peer-reviewed veterinary case report
Molecular discrimination of sheep bovine spongiform encephalopathy from scrapie.
- Journal:
- Emerging infectious diseases
- Year:
- 2011
- Authors:
- Pirisinu, Laura et al.
- Affiliation:
- Istituto Superiore di Sanita · Italy
Abstract
Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21470463/