Peer-reviewed veterinary case report
Coronavirus infection in dogs linked to blood changes in Pakistan
By Sulehria, M U et al.·Published in Tropical biomedicine·2020·Department of Veterinary Medicine·View original on PubMed →
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Original publication title: Molecular evidence and hematological alterations associated with the occurrence of coronavirus in domestic dogs in Pakistan.
- Species:
- dog
Plain-English summary
A group of dogs in Lahore, Pakistan, showed symptoms like vomiting and diarrhea, leading to the discovery of Canine Enteric Coronavirus (CCoV) in 35.1% of the tested dogs. Researchers collected fecal samples from 450 symptomatic dogs and found that the virus was linked to various risk factors, including breed, age, and living conditions. Blood tests from infected dogs revealed issues like anemia and changes in liver enzymes. This study highlights the widespread presence of CCoV in the area, suggesting that pet owners should be aware of these symptoms and consult their veterinarians for potential testing and treatment options.
People also search for: dog vomiting diarrhea treatment · canine coronavirus symptoms · dog blood test results · Lahore dog health issues
Abstract
Canine Enteric Coronavirus (CCoV) is one of the major enteric pathogen affecting dogs. This study aims to investigate the molecular prevalence, phylogenetic analysis, associated risk factors, and haemato-biochemical alterations in Canine Coronavirus in dogs in district Lahore, Pakistan. 450 fecal samples were collected from symptomatic dogs originating from various pet-clinics and kennels during 2018-2019. Samples were initially analyzed by sandwich lateral flow immunochromatographic assay and then further processed by RT-PCR (reverse transcriptase polymerase chain reaction) targeting the M gene followed by sequencing. RT-PCR based positive (n=20) and negative (n=20) dogs were samples for their blood for the haemato-biochemical analysis. A questionnaire was used to collect data from pet owners, in order to analyze the data for risk factors analysis by chi square test on SPSS. The prevalence of CCoV was 35.1%, and 23.8 % through Sandwich lateral flow immunochromatographic and RT-PCR respectively. Various risk factors like breed, age, sex, vomiting, diarrhea, sample source, body size, cohabitation with other animals, living environment, food, deworming history, contact with other animals or birds feces, and season were significantly associated with CCoV. The CCoV identified in Pakistan were 98% similar with the isolates from China (KT 192675, 1), South Korea (HM 130573, 1), Brazil (GU 300134, 1), Colombia (MH 717721, 1), United Kingdom (JX 082356, 1) and Tunisia (KX156806). Haematobiochemical alterations in CCoV affected dogs revealed anaemia, leucopenia, lymphopenia, neutrophilia, and decreased packed cell volume, and a significant increase in alkaline phosphate and alanine transaminase. It is concluded that infection with canine coronavirus appears widespread among dog populations in district Lahore, Pakistan. This study is the first report regarding the molecular detection and sequence analysis of CCoV in Pakistan.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33612749/