Peer-reviewed veterinary case report
Molecular localization techniques in the diagnosis and characterization of nonhuman primate infectious diseases.
- Journal:
- Veterinary pathology
- Year:
- 2014
- Authors:
- Mansfield, K G et al.
- Affiliation:
- Novartis Institutes for Biomedical Research · United States
Plain-English summary
This research discusses advanced techniques used to diagnose and study diseases in nonhuman primates, like monkeys and apes. Scientists have developed specific methods to identify various harmful germs, including viruses, bacteria, and fungi, in the tissues of these animals. Understanding how these germs interact with their hosts is crucial for improving these diagnostic methods. The review highlights the importance of these techniques in helping veterinarians and researchers better understand and manage infectious diseases in primates. Overall, these methods are essential for improving animal health and understanding new diseases.
Abstract
Molecular localization techniques remain important diagnostic and research tools for the pathologist evaluating nonhuman primate tissues. In situ hybridization and immunohistochemistry protocols have been developed for many important pathogens of nonhuman primates, including RNA and DNA viruses, prions, and bacterial, protozoal, and fungal pathogens. Such techniques will remain critical in defining the impact and relevance of novel agents on animal health and disease. A comparative pathology perspective often provides valuable insight to the best strategy for reagent development and can also facilitate interpretation of molecular localization patterns. Such a perspective is grounded in a firm understanding of microbe-host pathobiology. This review summarizes current molecular localization protocols used in the diagnosis of selected primate infectious diseases.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24168861/