Peer-reviewed veterinary case report
Molnupiravir treatment results for 18 cats with feline infectious
By Okihiro Sase·Published in Journal of Veterinary Internal Medicine·2023·View original on Semantic Scholar →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Molnupiravir treatment of 18 cats with feline infectious peritonitis: A case series
- Species:
- cat
Plain-English summary
Eighteen cats diagnosed with feline infectious peritonitis (FIP), a serious viral disease, were treated with a medication called molnupiravir. Owners gave their cats this treatment twice daily for about 12 weeks. While four cats sadly died or were euthanized shortly after starting the treatment, the remaining fourteen cats completed the course and showed no signs of the disease for several months afterward. Some cats experienced mild liver enzyme increases but recovered without any special treatment. This suggests that molnupiravir could be a promising option for treating FIP in cats.
People also search for: cat FIP treatment · molnupiravir for cats · feline infectious peritonitis symptoms · cat jaundice treatment · cat liver enzyme increase
Abstract
Abstract Background Feline infectious peritonitis (FIP) is a viral disease in cats, caused by certain strains of coronavirus and has a high case fatality rate. Objective This case series reports the outcomes of treatment of cats with FIP using molnupiravir. Animals Eighteen cats diagnosed with FIP at the You‐Me Animal Clinic, Sakura‐shi, Japan between January and August 2022, and whose owners gave informed consent to this experimental treatment. Methods For this prospective observational study, molnupiravir tablets were compounded in‐house at the You‐Me Animal Clinic. Owners administered 10‐20 mg/kg PO twice daily. Standard treatment duration was 84 days. Results Among 18 cats, 13 cats had effusive FIP and 5 had noneffusive FIP. Three cats had neurological or ocular signs of FIP before treatment. Four cats, all with effusive FIP, died or were euthanized within 7 days of starting treatment. The remaining 14 cats completed treatment and remained in remission at the time of writing (139‐206 days after starting treatment). Elevated serum alanine transaminase (ALT) activity was found in 3 cats, all at Days 7‐9, and all recovered without management. Two cats with jaundice were hospitalized, 1 during treatment (Day 37) and 1 with severe anemia at the start of treatment. Conclusions and Clinical Importance This case series suggests that molnupiravir might be an effective and safe treatment for domestic cats with FIP at a dose of 10‐20 mg/kg twice daily.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/37551843