Peer-reviewed veterinary case report
Monitoring α-Synuclein Proteotoxicity in Drosophila Models.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2019
- Authors:
- Szabo, Aron & Tofaris, George K
- Affiliation:
- Institute of Genetics
Abstract
Parkinson's disease is the second most common neurodegenerative disease without cure. It is characterized by α-synuclein accumulation and aggregation in dopaminergic and other types of neurons. Because α-synuclein accumulation leads to a toxic gain of function, its ectopic expression in Drosophila has been a useful in vivo model for testing modifiers of its toxicity. This chapter describes four assays: the rapid iterative negative geotaxis, rough eye phenotype, quantification of dopaminergic neuronal loss, and measurements of circadian effects.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30771179/