Mono-dimensional, two-dimensional and Doppler echocardiographic measurements in healthy Standardbred neonatal foals in the first 5 days of life.

Abstract

BACKGROUND: Bodyweight, age and breed influence the echocardiographic assessment of foals. There are no echocardiographic studies in Standardbred neonatal foals. OBJECTIVES: To describe echocardiographic values for selected variables, evaluate intra- and inter-observer variability and assess cardiac changes in the first 5&#x2009;days of life in healthy Standardbred neonatal foals. STUDY DESIGN: Prospective observational study. METHODS: Fifty-six healthy Standardbred neonatal foals were examined by transthoracic echocardiography using standard right parasternal and subcostal views at three time points: in the first 48&#x2009;h (T1), between 49 and 96&#x2009;h (T2), and 97 and 144&#x2009;h (T3) after birth. Descriptive statistics, variability analysis and linear mixed models assessed age-related changes in cardiac parameters. Intra/inter-observer variability was assessed using intraclass correlation coefficients (ICC). RESULTS: A total of 114 echocardiographic examinations were performed. Intra-observer agreement was excellent for most variables, while inter-observer agreement was excellent in approximately half. An increase in end-diastolic left ventricular internal diameter (T1: 5.3&#x2009;&#xb1;&#x2009;0.6&#x2009;cm; T3: 5.6&#x2009;&#xb1;&#x2009;0.8&#x2009;cm; p&#x2009;<&#x2009;0.01), left atrial diameter in the four-chamber view (T1: 5.8&#x2009;&#xb1;&#x2009;0.6&#x2009;cm; T3: 6.0&#x2009;&#xb1;&#x2009;0.6&#x2009;cm; p&#x2009;=&#x2009;0.01), end-diastolic aortic sinus diameter in the left ventricular outflow tract view (T1: 3.0&#x2009;&#xb1;&#x2009;0.3&#x2009;cm; T3: 3.2&#x2009;&#xb1;&#x2009;0.3&#x2009;cm; p&#x2009;<&#x2009;0.01) and peak velocity of the transmitral E wave (T1: 0.8&#x2009;&#xb1;&#x2009;0.1&#x2009;m/s; T3: 0.9&#x2009;&#xb1;&#x2009;0.1&#x2009;m/s; p&#x2009;<&#x2009;0.01) were observed over time. Additionally, a gradual decrease in the end-diastolic pulmonary diameter at the sinus (T1: 2.8&#x2009;&#xb1;&#x2009;0.3&#x2009;cm; T3: 2.5&#x2009;&#xb1;&#x2009;0.3&#x2009;cm; p&#x2009;<&#x2009;0.01) and at the valve (T1: 2.6&#x2009;&#xb1;&#x2009;0.3&#x2009;cm; T3: 2.5&#x2009;&#xb1;&#x2009;0.4&#x2009;cm; p&#x2009;=&#x2009;0.03) levels was noted. MAIN LIMITATIONS: Some variables have fewer individuals; coefficients of variation are moderate to high for some variables. CONCLUSIONS: Changes in echocardiographic variables in a healthy Standardbred neonatal foal population reflect a physiological adaptation of the cardiorespiratory system from foetal to extrauterine life. These observations can be used as a reference in the assessment of neonatal foals of similar age and weight.