Peer-reviewed veterinary case report
Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge.
- Journal:
- Infection and immunity
- Year:
- 2006
- Authors:
- Treviño, Sylvia R et al.
- Affiliation:
- U.S. Army Medical Research Institute of Infectious Diseases · United States
- Species:
- rodent
Abstract
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16495574/