Peer-reviewed veterinary case report
Blood cell ratios linked to inflammatory bowel disease in dogs
By Maria Chiara Marchesi et al.·Published in Animals·2024·Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy, CH·View original on DOAJ →
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Original publication title: Monocytes Count, NLR, MLR and PLR in Canine Inflammatory Bowel Disease
- Species:
- dog
Plain-English summary
A study involving 85 dogs, including 60 with inflammatory bowel disease (IBD) and 25 healthy dogs, found that certain blood tests can help diagnose IBD. The researchers looked at factors like monocyte count and different ratios of blood cells, which showed promise in distinguishing between dogs with IBD and healthy ones. Specifically, a higher monocyte count and certain blood ratios were linked to IBD. These findings suggest that simple blood tests could be useful tools for veterinarians when diagnosing dogs with digestive issues.
People also search for: dog inflammatory bowel disease symptoms · dog blood test for IBD · how to treat IBD in dogs
Abstract
This is an observational retrospective study on 85 client-owned dogs, 60 with IBD and 25 clinically healthy dogs. This study aims to assess the clinical relevance of some easy to obtain and cost-effective hematological parameters including red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in dogs with IBD. Comparison of clinical and laboratory parameters between dogs with IBD and control dogs was carried out and the ability to distinguish between these two groups of dogs was evaluated by calculating the area under the receiver-operating characteristic curve (AUCROC). Univariate and multivariable logistic regression analysis estimated the odds ratio (OR) of developing IBD with a 95% confidence interval (CI). MLR and monocytes count had the highest accuracy in facilitating the discrimination of dogs with IBD from control dogs with an AUCROC of 0.839 and 0.787 at the cut-off of >0.14% and >3.7 cells*10<sup>2</sup>/µL, respectively. According to two multivariable models, monocytes count (OR = 1.29; <i>p</i> = 0.016), NLR (OR = 1.80; <i>p</i> = 0.016), and MLR > 0.14 (OR = 8.07; <i>p</i> < 0.001) and PLR > 131.6 (OR = 4.35; <i>p</i> = 0.024) were significant and independent predictors of IBD for models one and two, respectively. Monocytes count and the hematological ratios MLR, NLR, and PLR can be useful in the diagnostic work-up of dogs with IBD.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/ani14060837