Peer-reviewed veterinary case report
Sugars that reduce Pseudomonas bacteria sticking to dog skin cells
By McEwan, Neil A et al.·Published in Veterinary dermatology·2008·Faculty of Veterinary Science, United Kingdom·View original on PubMed →
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Original publication title: Monosaccharide inhibition of adherence by Pseudomonas aeruginosa to canine corneocytes.
- Species:
- dog
Plain-English summary
A study found that certain sugars can help reduce the ability of a common bacteria, Pseudomonas aeruginosa, to stick to the skin cells of dogs. This was tested on six healthy dogs, and the sugars D-galactose, D-mannose, L-rhamnose, and dextrose were shown to significantly lower the bacteria's adherence. The best results came from using a combination of D-galactose, D-mannose, and L-rhamnose, which reduced adherence by nearly 53%. These findings suggest that these sugars might be useful in treating infections caused by this bacteria in dogs.
People also search for: dog skin infection treatment · Pseudomonas aeruginosa in dogs · D-mannose for dog infections
Abstract
The effect of D-galactose, D-mannose, L-rhamnose and dextrose on the adhesion to canine corneocytes by three strains of Pseudomonas aeruginosa was studied in six healthy dogs. Canine corneocytes were collected from the inner aspect of the pinna using adhesive discs (D-Squame). Half millimetre of bacterial suspension in phosphate-buffered saline (PBS) with or without the addition of a monosaccharide was placed over the corneocyte layer and incubated in moist chambers. Image analysis was used to quantify bacterial adherence to corneocytes. The three strains of Pseudomonas adhered well to canine corneocytes. All monosaccharides tested inhibited the adherence of Pseudomonas to canine corneocytes. The mean reduction in adhesion for individual sugars at a concentration of 0.1% was 40.2% (dextrose), 30.8% (L-rhamnose), 25.6% (D-galactose) and 19.4% (D-mannose). When D-galactose, D-mannose and L-rhamnose were used in combination at 0.1% concentration, the mean reduction in adherence was 52.9%. The monosaccharides studied may have a potential role in the management of Pseudomonas infections in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19086121/