Peer-reviewed veterinary case report
Morphine increases hippocampal viral load and suppresses frontal lobe CCL5 expression in the LP-BM5 AIDS model.
- Journal:
- Journal of neuroimmunology
- Year:
- 2014
- Authors:
- McLane, Virginia D et al.
- Affiliation:
- Graduate School of Biomedical Sciences and Engineering · United States
Abstract
Chronic opiate abuse accelerates the development of cognitive deficits in human immunodeficiency virus (HIV)-1 patients. To investigate morphine's effects on viral infection of the central nervous system, we applied chronic morphine treatment to the LP-BM5 murine acquired immunodeficiency syndrome (MAIDS) model. LP-BM5 infection induces proinflammatory cytokine/chemokine production, correlating to increased blood-brain barrier permeability. Morphine treatment significantly increased LP-BM5 viral load in the hippocampus, but not in the frontal lobe. Morphine reduced the chemokine CCL5 to non-infected levels in the frontal lobe, but not in the hippocampus. These data indicate a region-specific mechanism for morphine's effects on virally-induced neurocognitive deficits.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24629894/