Peer-reviewed veterinary case report
Morphofunctional analysis of experimental model of esophageal achalasia in rats.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2010
- Authors:
- Sabirov, A G et al.
- Affiliation:
- Kazan State Medical University
- Species:
- rodent
Abstract
We carried out a detailed analysis of rat model of esophageal achalasia previously developed by us. Manifest morphological and functional disorders were observed in experimental achalasia: hyperplasia of the squamous epithelium, reduced number of nerve fibers, excessive growth of fibrous connective tissue in the esophageal wall, high contractile activity of the lower esophageal sphincter, and reduced motility of the longitudinal muscle layer. Changes in rat esophagus observed in experimental achalasia largely correlate with those in esophageal achalasia in humans. Hence, our experimental model can be used for the development of new methods of disease treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21234445/