Peer-reviewed veterinary case report
Corneal cloudiness in Shiba dogs with GM1 gangliosidosis explained
By Nagayasu, Aya et al.·Published in The Journal of veterinary medical science·2008·Department of Veterinary Anatomy, Japan·View original on PubMed →
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Original publication title: Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis.
- Species:
- dog
Plain-English summary
A 5-year-old Shiba Inu was brought in with cloudy eyes, a symptom linked to a genetic condition called GM1 gangliosidosis, which affects the dog's metabolism and leads to neurological issues. The examination revealed that the cloudiness was due to changes in the cornea, specifically swelling of certain cells and a disorganized structure of collagen, which is essential for clear vision. Unfortunately, this condition is progressive and currently has no cure, but understanding the cause can help manage the dog's symptoms and monitor its health.
People also search for: Shiba Inu corneal opacity · GM1 gangliosidosis symptoms · dog cloudy eyes treatment
Abstract
GM1 gangliosidosis is one of the inherited metabolic lysosomal storage disorders characterized by neurological symptoms caused by beta-galactosidase deficiency and consequent accumulation of GM1 ganglioside in neuronal cells. Shiba dogs affected with GM1 gangliosidosis have been found to suffer from corneal opacity. In our morphological analysis, keratocyte enlargement was induced by abnormal intracellular accumulation of neutral carbohydrates, resulting in the loss of normal arrangement of collagen fibrils in the opaque cornea was found to be associated with the disorder. We therefore conclude that corneal opacity in this Shiba dog with GM1 gangliosidosis may be caused by neutral carbohydrate accumulation in lysosomes, swelling and dysfunction of keratocytes, and subsequent irregular arrangement of collagen fibrils in the corneal proper substance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18840960/