Peer-reviewed veterinary case report
Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging.
- Journal:
- Angewandte Chemie (International ed. in English)
- Year:
- 2020
- Authors:
- Ščupáková, Klára et al.
- Affiliation:
- Maastricht MultiModal Molecular Imaging Institute (M4I) · Netherlands
Abstract
The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32668069/