Peer-reviewed veterinary case report
Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi.
- Journal:
- Malaria journal
- Year:
- 2012
- Authors:
- Spence, Philip J et al.
- Affiliation:
- MRC National Institute for Medical Research · United Kingdom
Plain-English summary
This study looked at how the malaria parasite Plasmodium chabaudi, which affects rodents, can be transmitted by mosquitoes. Researchers developed a method to effectively transmit this parasite using a specific type of mosquito. They found that different strains of the parasite showed varying levels of strength when transmitted through mosquitoes, and that different hosts reacted differently to the infection. This research helps to better understand how malaria develops and spreads in a natural setting. Overall, the study successfully created a reliable way to study malaria transmission through mosquitoes.
Abstract
BACKGROUND: Serial blood passage of Plasmodium increases virulence, whilst mosquito transmission inherently regulates parasite virulence within the mammalian host. It is, therefore, imperative that all aspects of experimental malaria research are studied in the context of the complete Plasmodium life cycle. METHODS: Plasmodium chabaudi chabaudi displays many characteristics associated with human Plasmodium infection of natural mosquito vectors and the mammalian host, and thus provides a unique opportunity to study the pathogenesis of malaria in a single infection setting. An optimized protocol that permits efficient and reproducible vector transmission of P. c. chabaudi via Anopheles stephensi was developed. RESULTS AND CONCLUSIONS: This protocol was utilized for mosquito transmission of genetically distinct P. c. chabaudi isolates, highlighting differential parasite virulence within the mosquito vector and the spectrum of host susceptibility to infection initiated via the natural route, mosquito bite. An apposite experimental system in which to delineate the pathogenesis of malaria is described in detail.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23217144/