Peer-reviewed veterinary case report
Mouse models of osteoarthritis provide new research tools.
- Journal:
- Trends in pharmacological sciences
- Year:
- 2005
- Authors:
- Young, Marian F
- Affiliation:
- National Institute of Dental and Craniofacial Research · United States
- Species:
- rodent
Abstract
The options for pharmaceutical intervention of osteoarthritis are limited. There is therefore a crucial need for animal models of osteoarthritis that can be used as research tools for improving our understanding of the disease and for discovering and testing new treatments. Recently, a new mouse model of osteoarthritis was described in which the mice are unable to produce a bone morphogenetic protein (BMP) receptor specifically in joints. A comparison of this model to other models with different etiologies is presented. The findings suggest that all of the models could be linked molecularly.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15982479/