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Peer-reviewed veterinary case report

Mpox in a Patient With a Signal Transducer and Activator of Transcription 1 Gain-of-Function Mutation.

Journal:
Mayo Clinic proceedings
Year:
2025
Authors:
McHugh, Jack W et al.
Affiliation:
Mayo Clinic

Abstract

We report a case of mpox in a patient with a signal transducer and activator of transcription 1 gain-of-function mutation. Despite initial improvement with intravenous immune globulin and tecovirimat, severe symptoms developed and the patient died. This underscores the need for immune system optimization and effective virucidal treatments for mpox.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/40044363/