Peer-reviewed veterinary case report
MRI and nerve test results in a puppy with canine globoid cell
By Cozzi, F et al.·Published in The Journal of small animal practice·1998·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: MRI and electrophysiological abnormalities in a case of canine globoid cell leucodystrophy.
- Species:
- dog
Plain-English summary
A six-month-old West Highland white terrier was brought in for worsening neurological issues, including trouble moving and responding to sounds. Tests, including an MRI and nerve function tests, revealed a serious condition called canine globoid cell leucodystrophy (GCL), which affects the brain and nerves. Unfortunately, this condition is progressive and currently has no cure, but the tests can help veterinarians monitor how the disease is advancing.
People also search for: West Highland white terrier neurological disease · canine globoid cell leucodystrophy symptoms · dog MRI brain results
Abstract
A six-month-old West Highland white terrier with progressive, multifocal neurological disease was diagnosed with canine globoid cell leucodystrophy (GCL). Magnetic resonance imaging (MRI) of the brain was performed, as well as electrophysiological testing (including brainstem auditory evoked response, peripheral nerve conduction velocity, repetitive stimulation, F wave analysis and electromyography). MRI findings were consistent with diffuse, symmetrical white matter disease. Electrodiagnostic testing revealed evidence of peripheral neuropathy and an abnormal brainstem auditory evoked response. These observations were consistent with the pathological changes in central and peripheral white matter described for canine GCL, and resembled what has been described in human patients. It is believed that the tests may raise the suspicion of GCL in dogs and may aid in monitoring disease progression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9741878/