Peer-reviewed veterinary case report
Mucopolysaccharidosis VII causing bone and eye problems in a cat
By Schultheiss, P C et al.·Published in Veterinary pathology·2000·Department of Pathology, United States·View original on PubMed →
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Original publication title: Mucopolysaccharidosis VII in a cat.
- Species:
- cat
Plain-English summary
A domestic shorthair cat from California was diagnosed with a rare genetic disorder called mucopolysaccharidosis VII, which caused several serious health issues. The cat was small for its age and had noticeable deformities, including short limbs and problems with its hips and spine. Unfortunately, the cat passed away at just 21 months old, and a thorough examination revealed significant cellular damage throughout its body. This condition is linked to a deficiency in a specific enzyme, leading to the accumulation of harmful substances in the cells.
People also search for: cat mucopolysaccharidosis symptoms · domestic shorthair cat health issues · cat genetic disorders · why is my cat small for its age
Abstract
Mucopolysaccharidosis VII was diagnosed in a domestic shorthair cat from California. The cat was small and had multiple abnormalities, including a small body disproportionate to the size of the skull, angular deformities of the ribs, abnormally short forelimbs, luxating patellas, generalized epiphyseal dysplasia involving the vertebrae and long bones, cuboidal vertebrae, pectus excavatum, subluxation of both hips, osteosclerosis of the tentorium cerebelli and left petrous temporal bone, tracheal hypoplasia, and corneal clouding. Beta-glucuronidase activity was markedly decreased in peripheral blood leukocytes. The cat died at 21 months of age, and a complete necropsy was performed. Tissues were examined by light and transmission electron microscopy. Large clear, round vacuoles representing distended lysosomes were present in many epithelial and connective tissue cells, including fibrocytes, chondrocytes, smooth muscle cells, hepatocytes, astrocytes, and macrophages.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11055883/