Peer-reviewed veterinary case report
Imbalance of inflammation proteins in dogs with inflammatory bowel
By Maeda, Shingo et al.·Published in Veterinary journal (London, England : 1997)·2012·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Mucosal imbalance of interleukin-1β and interleukin-1 receptor antagonist in canine inflammatory bowel disease.
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) showed an imbalance in two important proteins that help regulate inflammation in the gut. Researchers found that dogs with IBD had lower levels of the IL-1 receptor antagonist (IL-1Ra), which normally helps control the inflammatory response, compared to healthy dogs. This imbalance was linked to more severe symptoms in the affected dogs. Understanding this imbalance could help veterinarians develop better treatments for dogs suffering from IBD.
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Abstract
Interleukin (IL)-1β is a key mediator of the inflammatory response. IL-1 receptor antagonist (IL-1Ra) regulates inflammation by functioning as an endogenous inhibitor of IL-1β. A disruption of the balance between IL-1β and IL-1Ra has been identified in human inflammatory bowel disease (IBD). The objective of this study was to determine whether there is an intestinal imbalance of IL-1β and IL-1Ra in canine IBD by comparing expression of IL-1β and IL-1Ra mRNA by real-time RT-PCR and expression of IL-1β and IL-1Ra protein by ELISA in 21 dogs with IBD, 15 dogs with intestinal lymphoma ('inflammatory' controls) and 20 healthy Beagles ('healthy' controls). A significant decrease in the intestinal IL-1Ra:IL-1β ratio of mRNA and protein was observed in IBD cases when compared with healthy control dogs. In contrast, a decrease in IL-1Ra:IL-1β ratio was not observed in dogs with intestinal lymphoma. The IL-1Ra:IL-1β protein ratio was negatively correlated with clinical severity in dogs with IBD. An intestinal imbalance between IL-1β and IL-1Ra production may play a role in the pathogenesis of canine IBD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22483380/