Peer-reviewed veterinary case report
How bladder receptors affect cats with feline interstitial cystitis
By Ikeda, Y et al.·Published in The Journal of urology·2009·Department of Medicine, United States·View original on PubMed →
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Original publication title: Mucosal muscarinic receptors enhance bladder activity in cats with feline interstitial cystitis.
- Species:
- cat
Plain-English summary
A group of cats with a painful bladder condition called feline interstitial cystitis were found to have increased activity in the bladder wall that could lead to more frequent and painful contractions. Researchers discovered that these cats had heightened sensitivity in their bladder's mucosal layer, which made their bladders react more strongly to certain medications. When the mucosal layer was removed, this sensitivity decreased significantly. Understanding these changes could help veterinarians develop better treatments for cats suffering from this painful condition.
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Abstract
PURPOSE: Interstitial cystitis is a chronic pelvic pain syndrome of which the origin and mechanisms involved remain unclear. In this study Ca(2+) transients in the bladder wall of domestic cats diagnosed with naturally occurring feline interstitial cystitis were examined. MATERIALS AND METHODS: Cross-sections of full-thickness bladder strips from normal cats and cats with feline interstitial cystitis were examined by optically mapping Ca(2+) transients and recording tension. Responses of Ca(2+) activity and detrusor contractions to pharmacological interventions were compared. In addition, pharmacological responses were compared in mucosa denuded preparations. RESULTS: Optical mapping showed that feline interstitial cystitis bladders had significantly more spontaneous Ca(2+) transients in the mucosal layer than control bladders. Optical mapping also demonstrated that feline interstitial cystitis bladders were hypersensitive to a low dose (50 nM) of the muscarinic receptor agonist arecaidine when the mucosal layer was intact. This hypersensitivity was markedly decreased in mucosa denuded bladder strips. CONCLUSIONS: In feline interstitial cystitis cat bladders there is increased Ca(2+) activity and sensitivity of muscarinic receptors in the mucosal layer, which can enhance smooth muscle spontaneous contractions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19157447/