Peer-reviewed veterinary case report
Stray dog with drug-resistant Trichophyton indotineae skin infection
By Oladzad, Vahid et al.·Published in Research in veterinary science·2024·Department of Mycology·View original on PubMed →
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Original publication title: Multi-drug resistance Trichophyton indotineae in a stray dog.
- Species:
- dog
Plain-English summary
A 2.5-year-old stray dog was found with hair loss, red and crusty skin on its body and legs. Tests revealed the cause was a type of fungus called Trichophyton indotineae, which was resistant to several common antifungal medications. However, a medication called luliconazole showed effectiveness against this fungus in lab tests. This finding is important for treating similar cases in dogs, as it suggests that luliconazole could be a good option for managing this type of skin infection.
People also search for: dog hair loss treatment · stray dog skin infection · antifungal medication for dogs · Trichophyton indotineae in dogs
Abstract
A 2.5-year-old stray dog showed signs of hair loss, mild skin crusting, and redness on extremities and trunk. The etiologic agent was confirmed as Trichophyton indotineae by sequencing of ITS region. Using the Clinical and Laboratory Standards Institute (CLSI M38-A3) guideline, antifungal susceptibility testing showed multidrug resistance phenotype against terbinafine (16 μg/mL), itraconazole, and some other tested antifungals (minimum inhibitory concentration, MIC≥16 μg/mL). However, luliconazole was found to be active in- vitro (0.016 μg/mL). Upon further studies, sequencing of SQLE gene showed an amino acids substitution of Phe397Leu and Ala448Thr, which is potentially linked to terbinafine resistance in Trichophyton species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38065018/