Peer-reviewed veterinary case report
Multi-Modal Imaging with a Toolbox of Influenza A Reporter Viruses.
- Journal:
- Viruses
- Year:
- 2015
- Authors:
- Tran, Vy et al.
- Affiliation:
- University of Wisconsin Madison · United States
Abstract
Reporter viruses are useful probes for studying multiple stages of the viral life cycle. Here we describe an expanded toolbox of fluorescent and bioluminescent influenza A reporter viruses. The enhanced utility of these tools enabled kinetic studies of viral attachment, infection, and co-infection. Multi-modal bioluminescence and positron emission tomography-computed tomography (PET/CT) imaging of infected animals revealed that antiviral treatment reduced viral load, dissemination, and inflammation. These new technologies and applications will dramatically accelerate in vitro and in vivo influenza virus studies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26473913/