Peer-reviewed veterinary case report
Imaging and treatment of spinal kidney tumor in a dog
By Slinkard, Powell T et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2022·College of Veterinary Medicine and Biomedical Sciences (CVMBS) (Slinkard, United States·View original on PubMed →
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Original publication title: Multi-modality imaging and therapeutics used in a case of canine spinal nephroblastoma.
- Species:
- dog
Plain-English summary
A 4-year-old male golden retriever was brought in for sudden weakness in his back legs, which was found to be caused by a tumor on his spinal cord. After imaging tests, the tumor was identified as a nephroblastoma (a type of kidney tumor) and the dog underwent surgery, radiation, and chemotherapy. Despite these aggressive treatments, the dog's condition worsened over time, and he was humanely euthanized after 350 days. Unfortunately, the cancer had spread significantly, affecting his spinal cord and lungs.
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Abstract
A 4-year-old castrated male golden retriever dog was brought to a veterinary teaching hospital for evaluation of acute progressive paraparesis. Neurological examination indicated a spinal cord lesion between the third thoracic vertebra and third lumbar vertebrae. Magnetic resonance imaging (MRI) revealed an intradural, extra medullary, and/or intramedullary mass centered over the eleventh and twelfth thoracic disc space. The dog underwent cytoreductive surgery and histopathologic analysis diagnosed a nephroblastoma. Following this, the dog underwent multimodal therapy, including multiple surgeries, 2 courses of radiation, and combination chemotherapy. The dog had serial restaging using MRI, computed tomography (CT), and fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography throughout the course of therapy. The dog survived 350 d from date of first presentation until humane euthanasia was elected due to worsening of neurologic status. During postmortem examination, extensive infiltration of the spinal cord by nephroblastoma cells was discovered as well as pulmonary metastatic disease. Key clinical message: Based on the literature search, this is the first case in which surgery, radiation therapy, and chemotherapy were all used for the treatment of canine spinal nephroblastoma. This case report details the aggressive nature of a case of canine spinal nephroblastoma despite multi-modal therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35919463/