Peer-reviewed veterinary case report
Blood clotting problems in dogs with sudden pancreatitis
By Nielsen, Lindsey et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2019·Angell Memorial Animal Hospital·View original on PubMed →
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Original publication title: Multicenter investigation of hemostatic dysfunction in 15 dogs with acute pancreatitis.
- Species:
- dog
Plain-English summary
A group of 15 dogs with acute pancreatitis (a painful inflammation of the pancreas) showed signs of blood clotting issues when tested. The tests revealed that these dogs had higher levels of certain blood markers, indicating they were more prone to forming clots than healthy dogs. The findings suggest that monitoring blood clotting in dogs with pancreatitis could help veterinarians manage their treatment better. With appropriate care, these dogs can receive the right interventions to improve their condition.
People also search for: dog pancreatitis symptoms · dog blood clotting issues · treatment for dog pancreatitis
Abstract
OBJECTIVE: To characterize hemostatic profiles in dogs with acute pancreatitis. DESIGN: Prospective and observational study. SETTING: Tertiary referral centers. ANIMALS: Fifteen client-owned dogs with acute pancreatitis enrolled between December 1, 2011 and June 1, 2012. MATERIALS AND METHODS: Blood samples were collected on admission for measurement of platelet count, PCV, thromboelastography (TEG), antithrombin, prothrombin time, activated partial thromboplastin time, D-dimer, von Willebrand factor, and fibrinogen values, which were compared to reference intervals derived from healthy dogs. The Wilcoxon rank-sum test was used to test for differences in continuous variables between study subjects and reference intervals. MEASUREMENTS AND MAIN RESULTS: Dogs with acute pancreatitis were globally hypercoagulable using TEG when compared with reference intervals. Dogs with acute pancreatitis had significantly higher D-dimers (1,144 μg/L vs 251 μg/L [6264.5 vs 1374.5 nmol/L]; P = 0.001), fibrinogen (837 vs 232 mg/dL [8.37 vs 2.32 g/L]; P < 0.001), and von Willebrand factor (92.9% vs 65.1%; P = 0.02) as well as significantly lower antithrombin (85.7% vs 120%; P < 0.001) and prothrombin time values (3.8 vs 7.6 sec; P < 0.001) than reference intervals. CONCLUSIONS: Laboratory evidence of hypercoagulability was present in dogs with acute pancreatitis. TEG may be useful in dogs with acute pancreatitis for monitoring response to therapy and guiding therapeutic interventions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31034751/