Peer-reviewed veterinary case report
Multidrug resistant E coli in dog and cat urinary infections
By Jańczak, Dawid et al.·Published in Annals of agricultural and environmental medicine : AAEM·2024·ANIMALLAB Veterinary Laboratory·View original on PubMed →
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Original publication title: Multidrug resistance of Escherichia coli isolated from the urinary bladder of dogs and cats with suspected urinary tract infections.
Plain-English summary
A group of dogs and cats with urinary tract infection (UTI) symptoms had urine samples tested for a common bacteria called E. coli. The study found that many of these bacteria were resistant to common antibiotics, especially in cats, where 100% of the samples showed resistance to ampicillin. In dogs, 68% were resistant to ampicillin, and 59% to a combination of ampicillin and sulbactam. This high level of antibiotic resistance is concerning because it can make treating infections more difficult and poses a risk of spreading resistant bacteria between pets and people.
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Abstract
INTRODUCTION AND OBJECTIVE: Escherichia coli is one of the most common bacteria isolated from urine samples collected from dogs and cats with urinary tract infection (UTI). Uncomplicated UTIs in dogs and cats can be treated with short courses of first-line antimicrobial drugs, e.g. amoxicillin, amoxicillin with clavulanic acid, or trimethoprim/sulfonamide. Recurrent or complicated UTIs often require long-term treatment with broad-spectrum antibiotics. However, the choice of drug should be based on antimicrobial susceptibility. MATERIAL AND METHODS: Between March - September 2022, E. coli isolates cultured from the urine of 66 dogs and 41 cats with UTI symptoms were tested for antimicrobial resistance by using Minimum Inhibitory Concentration (MIC). Antimicrobial susceptibility was tested for ampicillin, ampicillin/sulbactam, cefazolin, cefuroxime, aztreonam, gentamycin, amikacin, colistin, trimethoprim/sulfamethoxazole, ciprofloxacin, chloramphenicol and tetracycline. RESULTS: The highest prevalence of resistance was documented for ampicillin (68% in dogs, 100% in cats) and ampicillin with sulbactam (59% in dogs, 54% in cats). The most common antimicrobial resistance patterns of E. coli were ampicillin alone (12 isolates, 29.3% in cats) and beta-lactams, including aztreonam (14 isolates, 21.2% in dogs). CONCLUSIONS: High resistance to aztreonam (61% and 32% of isolates from dogs and cats, respectively), other beta-lactams, and fluoroquinolones should cause be alarm due to zoonotic potential and cross-transmission of antimicrobial-resistant microorganisms between animals and humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38940100/