Peer-reviewed veterinary case report
Dog with drug-resistant Klebsiella pneumoniae causing nasal infection
By Silva, Meire M et al.·Published in Diagnostic microbiology and infectious disease·2018·Academic Veterinary Medicine Unit, Brazil·View original on PubMed →
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Original publication title: Multidrug-resistant CTX-M-15-producing Klebsiella pneumoniae ST231 associated with infection and persistent colonization of dog.
- Species:
- dog
Plain-English summary
A dog with a serious nasal infection and breathing problems was diagnosed with a type of bacteria called Klebsiella pneumoniae that was resistant to many antibiotics. The dog had a thick, pus-like discharge from both nostrils and struggled to breathe. After testing, the vet found that the bacteria were resistant to several common treatments, so they used a strong antibiotic called meropenem, which helped control the infection. However, the dog continued to carry the bacteria for a long time, raising concerns about how it could spread between pets and humans.
People also search for: dog nasal discharge treatment · dog breathing problems Klebsiella infection · antibiotic-resistant dog infections
Abstract
Extended spectrum β-lactamase (ESBL)-producing bacterial infections in veterinary medicine are a clinical and epidemiological challenge. We report a case of CTX-M-15-producing Klebsiella pneumoniae infection followed by persistent colonization, in a dog presenting with bilateral purulent nasal discharge and dyspnea. In this regard, 5 broad-spectrum cephalosporin-resistant K. pneumoniae isolates were recovered from infection and surveillance cultures, collected during 1 year and eight months study. Genomic analysis of a representative clone of K. pneumoniae (KpPB76) revealed the presence of the human-associated lineage ST231, whereas resistome data confirmed the presence of genes conferring resistance to aminoglycosides, β-lactams, fluoroquinolones, fosfomycin, phenicols, sulfonamides, tetracyclines and trimethoprim. In the absence of therapeutic options, meropenem therapy was used, contributing to the control of infection during persistent carriage of K. pneumoniae CTX-M-15/ST231. Persistent colonization of companion animals with ESBL-producing bacteria could be result from a variety of situations, including multi introduction from the owner or household family members to pets, or from environmental exposure; whereas colonized animals may serve as an important source for the spread of ESBL-producing strains in the human-animal interface.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30025966/