Peer-reviewed veterinary case report
Dog with drug-resistant Klebsiella pneumoniae infection and long-term
By Meire M Silva et al.·Published in Diagnostic microbiology and infectious disease·2018·View original on Semantic Scholar →
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Original publication title: Multidrug-resistant CTX-M-15-producing Klebsiella pneumoniae ST231 associated with infection and persistent colonization of dog.
- Species:
- dog
Plain-English summary
A dog with a serious infection caused by a resistant bacteria called Klebsiella pneumoniae was brought in with symptoms of a runny nose and trouble breathing. After testing, it was found that the bacteria were resistant to many common antibiotics, making treatment challenging. The veterinarian used a stronger antibiotic called meropenem, which helped control the infection. However, the dog continued to carry the bacteria for a long time, raising concerns about spreading it to humans or other animals.
People also search for: dog nasal discharge · dog breathing problems · Klebsiella pneumoniae treatment · antibiotic-resistant infections in dogs · dog persistent infection treatment
Abstract
Extended spectrum β-lactamase (ESBL)-producing bacterial infections in veterinary medicine are a clinical and epidemiological challenge. We report a case of CTX-M-15-producing Klebsiella pneumoniae infection followed by persistent colonization, in a dog presenting with bilateral purulent nasal discharge and dyspnea. In this regard, 5 broad-spectrum cephalosporin-resistant K. pneumoniae isolates were recovered from infection and surveillance cultures, collected during 1 year and eight months study. Genomic analysis of a representative clone of K. pneumoniae (KpPB76) revealed the presence of the human-associated lineage ST231, whereas resistome data confirmed the presence of genes conferring resistance to aminoglycosides, β-lactams, fluoroquinolones, fosfomycin, phenicols, sulfonamides, tetracyclines and trimethoprim. In the absence of therapeutic options, meropenem therapy was used, contributing to the control of infection during persistent carriage of K. pneumoniae CTX-M-15/ST231. Persistent colonization of companion animals with ESBL-producing bacteria could be result from a variety of situations, including multi introduction from the owner or household family members to pets, or from environmental exposure; whereas colonized animals may serve as an important source for the spread of ESBL-producing strains in the human-animal interface.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/30025966