Peer-reviewed veterinary case report
Platelet rich plasma injection effects in dogs after knee surgery
By Aryazand, Yazdan et al.·Published in PloS one·2023·VCA West Los Angeles, United States·View original on PubMed →
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Original publication title: Multifactorial assessment of leukocyte reduced platelet rich plasma injection in dogs undergoing tibial plateau leveling osteotomy: A retrospective study.
- Species:
- dog
Plain-English summary
A group of dogs with torn knee ligaments underwent a surgery called Tibial Plateau Leveling Osteotomy (TPLO) to help fix the issue. Some of these dogs received an injection of leukocyte reduced platelet rich plasma (lPRP) during their surgery, while others did not. The dogs that received the lPRP showed better healing on X-rays and less lameness during follow-up visits compared to those who didn't get the injection. However, there was no difference in infection rates or the need for implant removal between the two groups. Overall, using lPRP during TPLO surgery helped improve recovery for the dogs that received it.
People also search for: dog knee surgery recovery · TPLO surgery for dogs · lPRP injection benefits for dogs
Abstract
This study assessed the effects of concurrent intra-articular injection and Tibial Plateau Leveling Osteotomy (TPLO) plate surface treatment with leukoreduced platelet rich plasma (lPRP) on outcomes of dogs undergoing TPLO. A retrospective study of medical records for cases presenting from January 2018 to December 2020 was performed. Client-owned dogs with naturally occurring cranial cruciate ligament rupture that underwent TPLO surgery were divided into two groups. The lPRP group included cases that underwent intra-articular injection and plate surface treatment at the time of their TPLO. The control group (C) underwent TPLO without PRP treatment. Data analyzed included: presence of surgical site infection, implant removal rate, degree of change in OA progression score, lameness score progression and radiographic bone healing. The short- and long-term complication rate, hospitalization and antibiotic therapy were also compared between the groups. Descriptive statistics, comparison analyses (Chi square test, t-test, Fisher's exact test) and multi-level logistic regression models were used for statistical analysis. A total of 110 cases met the study inclusion criteria: 54 = lPRP, 56 = C. There were no significant differences between groups with regard to gender, age, presence of meniscal tear, weight, or body condition score. Significant findings included: improved radiographic healing of the osteotomy in the lPRP group, improved global OA scores in the lPRP group, and improved lameness score at recheck examination in the lPRP group. There was no significant difference between the lPRP and C group with regard to surgical site infection and implant removal rate. Concurrent intra-articular injection and plate surface treatment with leukocyte reduced PRP at the time of TPLO, is beneficial in slowing the progression of OA, hastening the radiographic evidence of osteotomy healing, and improved lameness score on recheck examination. Leukocyte reduced PRP was not a significant factor in reducing SSI or implant removal rate.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37390083/