Peer-reviewed veterinary case report
Multifocal pleural cystic squamous metaplasia in a horse with chronic obstructive bronchopneumonia.
- Journal:
- Veterinary pathology
- Year:
- 2004
- Authors:
- Baum, B et al.
- Affiliation:
- berit.baum@tiho-hannover.de · Germany
- Species:
- horse
Plain-English summary
A 10-year-old Knabstrupper stallion had to be put to sleep because he was having serious trouble breathing and couldn't exercise. After he passed away, a thorough examination showed that he had severe lung damage and inflammation in the lining around his lungs. There were also several abnormal growths on the surface of his lungs that were made up of thickened tissue and cysts. Further testing revealed specific changes in the cells of these growths. Unfortunately, the horse's condition was very serious, and the treatment options were not effective.
Abstract
A 10-year-old Knabstrupper stallion was euthanatized because of severe dyspnea and exercise intolerance. Postmortem examination revealed diffuse severe alveolar emphysema and chronic fibrosing pleuritis of the caudal lung. Parts of both caudal lung lobes were covered with multiple raised firm gray to yellow plaques. Histologically, these areas consisted of circumscribed pleural fibroses and cysts of metaplastic keratinizing squamous epithelium. Immunohistochemistry revealed intense labeling for cytokeratins 5/6 and 10. In addition, caudal lung lobes were severely affected by a chronic partially obliterative bronchiolitis and peribronchiolitis with multifocal pleural involvement.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15347830/