Peer-reviewed veterinary case report
Multiorgan dysfunction in cats with sepsis and survival chances
By Troìa, Roberta et al.·Published in Journal of feline medicine and surgery·2019·Department of Veterinary Medical Science, Italy·View original on PubMed →
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Original publication title: Multiorgan dysfunction syndrome in feline sepsis: prevalence and prognostic implication.
- Species:
- cat
Plain-English summary
A group of 43 cats diagnosed with sepsis were hospitalized and monitored for signs of multiorgan dysfunction syndrome (MODS), which means two or more organs weren't working properly. Many of these cats showed signs of organ dysfunction upon admission, and the situation worsened for some during their stay. The study found that cats with kidney and heart problems had a higher chance of not surviving. This highlights the importance of checking for organ issues in cats with sepsis to improve their chances of recovery.
People also search for: cat sepsis symptoms · feline kidney problems · cat heart failure treatment
Abstract
OBJECTIVES: The current study was designed to evaluate the prevalence and prognostic significance of multiorgan dysfunction syndrome (MODS) in cats with sepsis. METHODS: Cats hospitalised in the intensive care unit of a veterinary university hospital with a diagnosis of sepsis were prospectively enrolled and divided according to disease severity and outcome (survivors; non-survivors). The feline acute patient physiological and laboratory evaluation (APPLE) scores were calculated upon admission, as previously described. Specific criteria to identify selected organ dysfunction (hepatic, renal, respiratory, cardiocirculatory, haemostatic) were adapted from the available human and veterinary literature, and evaluated at baseline and at the end of hospital stay. MODS was defined as the presence of at least two dysfunctional organs simultaneously. Non-parametric statistics were used for comparisons. Univariate and multivariate regression analyses to evaluate significant risk factors for death were carried out. Correlations between variables were assessed by the Spearman's rank correlation coefficient. Significance was set at P <0.05. RESULTS: A total of 43 cats with heterogeneous sources of sepsis were included. MODS was identified in 25/43 cats upon admission and in 32/43 cats at the end of hospital stay. Regression analyses showed a significantly elevated odds ratio for mortality for the presence of MODS, renal and cardiovascular dysfunction upon admission, as well as for the number of dysfunctional organs. The latter was the only variable retained by the model from the multivariate binary logistic regression analysis. Significant correlations were documented between the number of dysfunctional organs and the APPLE scores. CONCLUSIONS AND RELEVANCE: MODS is a frequent complication of feline sepsis, and is associated with worse outcomes. In particular, renal and cardiovascular dysfunction significantly increase the odds for death. Hence, systematic screening for organ dysfunction is advocated in cats with sepsis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30099963/