Peer-reviewed veterinary case report
Border Collie with trapped neutrophil syndrome and organ inflammation
By Zoto, Alyssa et al.·Published in Journal of veterinary internal medicine·2022·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Multiorgan neutrophilic inflammation in a Border Collie with "trapped" neutrophil syndrome.
- Species:
- dog
Plain-English summary
A young Border Collie was brought to the vet with signs of illness due to a rare condition called trapped neutrophil syndrome, which causes low levels of a type of white blood cell called neutrophils. Tests showed that while the neutrophils were not present in the blood, they were causing inflammation in various organs. This condition is linked to a genetic mutation that affects how long these cells survive. The vet diagnosed the dog based on blood tests and bone marrow evaluation, and while the inflammation was concerning, understanding the condition helped guide treatment.
People also search for: Border Collie trapped neutrophil syndrome · dog low white blood cell count · neutrophil inflammation in dogs
Abstract
Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We document the case of a young Border Collie diagnosed with trapped neutrophil syndrome based on clinical features, blood and bone marrow evaluation, and presence of the associated homozygous mutation. Results from flow cytometric and storage studies suggested lower neutrophil survival time. The dog had substantial neutrophilic inflammation in multiple organs, indicating that neutrophils could leave the marrow and enter tissues, making the term "trapped" neutrophil syndrome a misnomer.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36239343/